肌球蛋白輕鏈激酶（英語(yǔ)：Myosin light-chain kinase，MYLK 或 MLCK）是一類(lèi)絲氨酸/蘇氨酸特異性蛋白激酶，通過(guò)磷酸化來(lái)調(diào)節(jié)II型肌球蛋白的輕鏈[3]。
亞型
現(xiàn)存四種MLCK亞型[4]主要分布于不同肌細(xì)胞：
功能
另見(jiàn)
參考文獻(xiàn)
- ↑ RCSB Protein Data Bank - Structure Summary for 3KF9 - Crystal structure of the SdCen/skMLCK complex.
- ↑ RCSB Protein Data Bank - Structure Summary for 2X4F - The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156..
- ↑ Gao Y, Ye LH, Kishi H, Okagaki T, Samizo K, Nakamura A, Kohama K. Myosin light chain kinase as a multifunctional regulatory protein of smooth muscle contraction. IUBMB Life. June 2001, 51 (6): 337–44. doi:10.1080/152165401753366087. PMID 11758800.
- ↑ Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. The protein kinase complement of the human genome. Science. December 2002, 298 (5600): 1912–34. doi:10.1126/science.1075762. PMID 12471243.
延伸閱讀
- Strausberg RL, Feingold EA, Grouse LH, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/ Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.]. Proc. Natl. Acad. Sci. U.S.A.. 2003, 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. PMC 139241.
- Gerhard DS, Wagner L, Feingold EA, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/ The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).]. Genome Res.. 2004, 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. PMC 528928.
- Clayburgh DR, Rosen S, Witkowski ED, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1237105/ A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability.]. J. Biol. Chem.. 2005, 279 (53): 55506–13. doi:10.1074/jbc.M408822200. PMID 15507455. PMC 1237105.
- Wang F, Graham WV, Wang Y, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1237049/ Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression.]. Am. J. Pathol.. 2005, 166 (2): 409–19. doi:10.1016/S0002-9440(10)62264-X. PMID 15681825. PMC 1237049.
- Russo JM, Florian P, Shen L, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1237051/ Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure.]. Gastroenterology. 2005, 128 (4): 987–1001. doi:10.1053/j.gastro.2005.01.004. PMID 15825080. PMC 1237051.
- Shimizu S, Yoshida T, Wakamori M, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1464317/ Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells.]. J. Physiol. (Lond.). 2006, 570 (Pt 2): 219–35. doi:10.1113/jphysiol.2005.097998. PMID 16284075. PMC 1464317.
- Kim MT, Kim BJ, Lee JH, et al.. Involvement of calmodulin and myosin light chain kinase in activation of mTRPC5 expressed in HEK cells.. Am. J. Physiol., Cell Physiol.. 2006, 290 (4): C1031–40. doi:10.1152/ajpcell.00602.2004. PMID 16306123.
- Kimura K, Wakamatsu A, Suzuki Y, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129/ Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.]. Genome Res.. 2006, 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. PMC 1356129.
- Connell LE, Helfman DM. Myosin light chain kinase plays a role in the regulation of epithelial cell survival.. J. Cell. Sci.. 2007, 119 (Pt 11): 2269–81. doi:10.1242/jcs.02926. PMID 16723733.
- Seguchi O, Takashima S, Yamazaki S, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1978424/ A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart.]. J. Clin. Invest.. 2007, 117 (10): 2812–24. doi:10.1172/JCI30804. PMID 17885681. PMC 1978424.
外部鏈接
肌球蛋白輕鏈激酶引用了美國(guó)國(guó)家醫(yī)學(xué)圖書(shū)館提供的資料，這些資料屬于公共領(lǐng)域。
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肌球蛋白輕鏈激酶（EC 2.7.11.18）
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暫無(wú)錄入
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暫無(wú)錄入
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暫無(wú)錄入
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參考來(lái)源
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